Arno Bourgonje
I am a Postdoctoral Fellow in the Division of Gastroenterology at the Icahn School of Medicine at Mount Sinai in New York City (NY, United States), advised by prof. Saurabh Mehandru and prof. Jean-Frédéric Colombel. My research is focused on the identification, application, and validation of biomarker signatures in patients affected by inflammatory bowel diseases (IBD). I am particularly interested in the use of high-throughput immunological techniques and complex data science to interrogate immune system alterations in IBD and identify novel biomarkers for early diagnosis, disease complications and long-term disease prognosis of patients with IBD.
I completed an MD/PhD trajectory (MD: 2020, summa cum laude; PhD: 2023, cum laude) at the University of Groningen and University Medical Center Groningen in the Netherlands. My PhD focused on the identification of novel biomarker signatures for patients with IBD through exploration of multiple biological systems (e.g., the immune system and gut microbiome) and -mechanisms (e.g., oxidative stress and inflammation). My current position is supported by a NWO Rubicon fellowship.
Professional experience
2023 – 2025
Postdoctoral researcher / physician-scientist
Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States
2023 – 2025
Postdoctoral researcher / physician-scientist
Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen
2021 – 2023
Physician-not-in-training
Municipal Health Services Groningen (GGD), Groningen, the Netherlands
2019 – 2021
Project assistant
Development of exams and tests for the longitudinal examination program of the Medicine master G2020 curriculum and national Progress Test of Medicine (iVTG), University of Groningen
Education
2018 – 2022
MD/PhD trajectory
Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen
2016 – 2020
MSc Medicine
University Medical Center Groningen, University of Groningen
2014 – 2016
Honours College
University of Groningen
2013 – 2016
BSc Medicine
University Medical Center Groningen, University of Groningen
Highlighted Publications
Gastroenterology, 2024
Bourgonje AR, Ungaro RC, Mehandru S, Colombel JF. Targeting the Interleukin 23 Pathway in Inflammatory Bowel Disease. Gastroenterology. 2024:S0016-5085(24)05124-2.
Microbiome, 2024
Bourgonje AR, Hörstke NV, Fehringer M, et al. Systemic antibody responses against gut microbiota flagellins implicate shared and divergent immune reactivity in Crohn’s disease and chronic fatigue syndrome. Microbiome. 2024;12(1):141.
Immunity, 2023
Bourgonje AR, Andreu-Sánchez S, Vogl T, et al. Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures. Immunity. 2023;56(6):1393-1409.e6.
Nature Communications, 2024
Hu S*, Bourgonje AR*, Gacesa R, et al. Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease. Nat Commun. 2024;15(1):1470.
Inflammatory Bowel Diseases, 2024
Otten AT, van der Meulen HH, Steenhuis M, Loeff FC, Touw DJ, Kosterink JGW, Frijlink HW, Rispens T, Dijkstra G, Visschedijk MC, Bourgonje AR. Clinical Validation of a Capillary Blood Home-Based Self-Sampling Technique for Monitoring of Infliximab, Vedolizumab, and C-Reactive Protein Concentrations in Patients With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2024;30(3):325-335.
Redox Biology, 2023
Vlaming-van Eijk LE, Bulthuis MLC, van der Gun BTF, Wold KI, Vincenti Gonzalez MF, de Borst MH, den Dunnen WFA, Hillebrands JL, van Goor H, Tami A, Bourgonje AR. Systemic oxidative stress associates with the development of post-COVID-19-syndrome in non-hospitalized individuals. Redox Biol. 2024;76:103310.