Publications
Peer-reviewed publications as of June 1, 2024: 100 original articles, letters and reviews; h-index: 20; i10-index: 38; total citations: 3,356 (Google Scholar statistics).
Asterisks (*) indicate equal author contributions / shared authorships.
2024
Bourgonje AR, Dubinsky MC, Keizer RJ, Dreesen E, Mian P. Advances in personalized dosing in inflammatory bowel diseases. Trends Pharmacol Sci 2024; in press.
Geertsema S, Geertsema P, Kieneker LM, Abdulle AE, la Bastide-van Gemert S, Bakker SJL, Dullaart RPF, Dijkstra G, Gansevoort RT, Faber KN, van Goor H, Bourgonje AR. Serum peroxiredoxin-4, a predictive biomarker linking new-onset chronic kidney disease to oxidative stress: a prospective population-based cohort study. Redox Biol 2024;76:103408. doi: 10.1016/j.redox.2024.103408.
Bloemen H, Livanos AE, Martins A, Dean R, Bravo AC, Bourgonje AR, Tankelevich M, Herb J, Cho J, Santos AA, Rodrigues CMP, Petralia F, Colombel JF, Bowlus C, Schiano T, Torres J, Levy C, Mehandru S. Anti-integrin αvβ6 autoantibodies are increased in patients with PSC with concomitant IBD and correlate with liver disease severity. Clin Gastroenterol Hepatol. 2024; doi: 10.1016/j.cgh.2024.10.005.
Bredero QM, Fleer J, Blom DM, Bourgonje AR, Dijkstra G, Schroevers MJ. The substantial role of sleep, stress and physical activity in persistent high levels of fatigue in patients with inflammatory bowel disease: A longitudinal trajectory study. J Crohns Colitis. 2024; jjae163. doi: 10.1093/ecco-jcc/jjae163.
Cossarini F, Shang J, Krek A, Al-Taie Z, Hou R, Canales-Herrerias P, Tokuyama M, Tankelevich M, Tillowiz A, Jha D, Livanos AE, Leyre L, Uzzan M, Martinez-Delgado G, Taylor MD, Sharma K, Bourgonje AR, Cruz M, Ioannou G, Dawson T, D’Souza D, Kim-Schulze S, Akm A, Aberg JA, Chen BK, Gnjatic S, Polydorides AD, Cerutti A, Argmann C, Vujkovic-Cvijin I, Suarez-Farinas M, Petralia F, Faith JJ, Mehandru S. Gastrointestinal germinal center B cell depletion and reduction in IgA+ plasma cells in HIV-1 infection. Sci Immunol. 2024; 9(100):eado0090. doi: 10.1126/sciimmunol.ado0090.
Vlaming-van Eijk LE, Bulthuis MLC, Veloo ACM, Wold KI, Vincenti González MF, den Dunnen WFA, van der Gun BTF, Hillebrands JL, van Goor H, Tami A, Bourgonje AR. Systemic oxidative stress associates with the development of post-COVID-19 syndrome in non-hospitalized individuals. Redox Biol. 2024; 76:103310. doi: 10.1016/j.redox.2024.103310.
Bourgonje AR, Hörstke NV, Fehringer M, Innocenti G, Vogl T. Systemic antibody responses against gut microbiota flagellins implicate shared and divergent immune reactivity in Crohn’s disease and chronic fatigue syndrome. Microbiome 2024;12(1):141. doi: 10.1186/s40168-024-01858-1.
Bourgonje AR, Ungaro RC, Mehandru S, Colombel JF. Targeting the IL-23 Pathway in Inflammatory Bowel Disease. Gastroenterology 2024; S0016-5085(24)05124-2. doi: 10.1053/j.gastro.2024.05.036.
Blok EL, Burger RJ, van Bergeijk JE, Bourgonje AR, van Goor H, Ganzevoort W, Gordijn SJ. Oxidative stress biomarkers for fetal growth restriction in umbilical cord blood: A scoping review. Placenta 2024;154:88-109. doi: 10.1016/j.placenta.2024.06.018.
Bourgonje AR, Visschedijk MC, Festen EAM, Weersma RK, Dijkstra G. Treatment strategies and biomarkers in Crohn’s disease: the PROFILE trial. Lancet Gastroenterol Hepatol 2024;9(7):590-591. doi: 10.1016/S2468-1253(24)00120-1.
Andreu-Sánchez S, Ripoll-Cladellas A, Culinscaia A, Bulut O, Bourgonje AR, Netea MG, Lansdorp P, Aubert G, Bonder MJ, Franke L, Vogl T, van der Wijst MGP, Melé M, Van Baarle D, Fu J, Zhernakova A. Antibody signatures against viruses and microbiome reflect past and chronic exposures and associate with aging and inflammation. iScience 2024; doi.org/10.1101/2024.01.12.24301197.
Visser K, Ciubotariu D, de Koning ME, Jacobs B, van Faassen M, van der Ley C, Mayer AR, Meier TB, Bourgonje AR, Kema IP, van Goor H, van der Naalt J, van der Horn HJ. Exploring the kynurenine pathway in mild traumatic brain injury: A longitudinal study. J Neurochem 2024; in press. doi: 10.1111/jnc.16137.
Struiken STL, Lobee D, van Tuinen EL, Touw DJ, van der Vaart H, Bourgonje AR, Rottier BL, Koppelman GH, Mian P. Evaluation of Target Attainment for Tobramycin in Children and Adults with Cystic Fibrosis. J Clin Med 2024;13(9):2641. doi: 10.3390/jcm13092641.
Bourgonje AR, Bourgonje MF, Kieneker LM, la Bastide-van Gemert S, Nilsen T, Hidden C, Gansevoort RT, Mulder DJ, Bakker SJL, Dullaart RPF, van Goor H, Abdulle AE. A Prospective Study of the Association Between Plasma Calprotectin Levels and New-Onset CKD in the General Population. Kidney Int Rep 2024;9(5):1265-1275. doi: 10.1016/j.ekir.2024.02.1392.
Bourgonje AR, Geertsema S, Holstein HJ, Bulthuis MLC, Dijkstra G, Faber KN, van Goor H. Evaluating Serum Free Thiols in Inflammatory Bowel Disease: Contribution of Albumin to Extracellular Free Thiol Status. Inflamm Bowel Dis 2024; izae102. doi: 10.1093/ibd/izae102.
Barth I, Stevens CL, Strokap JC, Campmans-Kuijpers MJE, Bourgonje AR, Dijkstra G. Letter: Diet-microbiome interactions in inflammatory bowel disease-Navigating towards individualized dietary strategies. Aliment Pharmacol Ther 2024;59(9):1154-1155. doi: 10.1111/apt.17927.
Geertsema S, Fagundes RR, Otten AT, Dijkstra G, Faber KN, Bourgonje AR. Interleukin-18 Inhibition in Inflammatory Bowel Disease: A Delicate Balance. Inflamm Bowel Dis 2024;30(4):693-694. doi: 10.1093/ibd/izae042.
Bourgonje AR, Bourgonje MF, Sokooti S, la Bastide-van Gemert S, Nilsen T, Hidden C, Gansevoort RT, Mulder DJ, Hillebrands JL, Bakker SJL, van Beek A, Dullaart RPF, van Goor H, Abdulle AE. Plasma calprotectin levels associate with new-onset type 2 diabetes in the general population: a prospective cohort study. J Clin Endocrinol Metab 2024;dgae130. doi: 10.1210/clinem/dgae130.
van Eijk LE, Bourgonje AR, Messchendorp AL, Bulthuis MLC, Reinders-Luinge M, Doornbos- van der Meer B, Westra H, den Dunnen WFA, Hillebrands JL, Sanders JSF, van Goor H. Systemic oxidative stress may be associated with reduced IgG antibody titers against SARS-CoV-2 in vaccinated kidney transplant recipients: A post-hoc analysis of the RECOVAC-IR observational study. Free Radic Biol Med 2024;215:14-24. doi: 10.1016/j.freeradbiomed.2024.02.018.
Hu S*, Bourgonje AR*, Gacesa R, Jansen BH, Bangma A, Hidding I, Festen EAM, van Dullemen HM, Visschedijk MC, Dijkstra G, Harmsen HJM, Vich Vila A, Spekhorst LM, Weersma RK. Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease. Nat Commun 2024;15(1):1470. doi: 10.1038/s41467-024-45855-2.
Briggs K, Tomar V, Ollberding N, Haberman Y, Bourgonje AR, Hu S, Sunawar L, Kugathasan S, Weersma RK, Denson LA, Melia JMP. Crohn’s Disease-Associated Pathogenic Mutation in the Manganese Transporter ZIP8 Shifts the Ileal and Rectal Mucosal Microbiota Implicating Aberrant Bile Acid Metabolism. Inflamm Bowel Dis 2024;izae003. doi: 10.1093/ibd/izae003.
van Eijk LE, Bourgonje AR, Mastik MF, Snippe D, Vos W, Bugiani M, Smit JM, Berger SP, van der Voort PHJ, van Goor H, den Dunnen WFA, Hillebrands JL. Viral presence and immunopathology in a kidney transplant recipient with fatal COVID-19: a clinical autopsy report. J Leukoc Biol 2024;qiae016. doi: 10.1093/jleuko/qiae016.
Feenstra ME, Bourgonje MF, Bourgonje AR, Schoots MH, Prins JR, van Goor H, Ganzevoort W, Gordijn SJ. Systemic Oxidative Stress in Severe Early-Onset Fetal Growth Restriction Associates with Concomitant Pre-Eclampsia, Not with Severity of Fetal Growth Restriction. Antioxidants 2024;13(1):46. doi: 10.3390/antiox13010046.
Visser K, de Koning ME, Ciubotariu D, Kok MGJ, Sibeijn-Kuiper AJ, Bourgonje AR, van Goor H, van der Naalt J, van der Horn HJ. An exploratory study on the association between blood-based biomarkers and subacute neurometabolic changes following mild traumatic brain injury. J Neurol 2024;271(4):1985-1998. doi: 10.1007/s00415-023-12146-7.
Bourgonje AR, Bourgonje MF, Kieneker LM, la Bastide-van Gemert S, Nilsen T, Hidden C, Gansevoort RT, Bakker SJL, Mulder DJ, Dullaart RPF, Abdulle AE, van Goor H. Plasma Calprotectin Levels Associate With New-Onset Hypertension in the General Population: A Prospective Cohort Study. J Am Heart Assoc 2024;13(1):e031458. doi: 10.1161/JAHA.123.031458.
2023
Bourgonje AR, van Goor H, Bakker SJL, Bilo HJG, Dullaart RPF, van Dijk PR. Serum levels of peroxiredoxin-4, a biomarker of oxidative stress, are associated with the development of nephropathy in patients with type 2 diabetes (Zodiac-65). Free Radic Biol Med 2023;212:186-190. doi: 10.1016/j.freeradbiomed.2023.12.025.
Geertsema S, Jansen BH, van Goor H, Dijkstra G, Faber KN, Bourgonje AR. Unsuitability of the Oxidation-Reduction Potential Measurement For Quantification of Fecal Redox Status in Inflammatory Bowel Disease. Biomedicines 2023;11(12):3107. doi: 10.3390/biomedicines11123107.
Versluis J, Bourgonje AR, Touw DJ, Meinderts JR, Prins JR, de Jong MFC, Mian P. Pharmacokinetics of Tacrolimus in Pregnant Solid-Organ Transplant Recipients: A Retrospective Study. J Clin Pharmacol 2024;64(4):428-436. doi: 10.1002/jcph.2393.
Bourgonje AR, Mian P. Identifying Phenotypic Determinants of Infliximab Target Concentrations in Inflammatory Bowel Disease: Towards Personalized Evidence-Based Dosing Regimens. Am J Gastroenterol 2023;118(12):2308-2309. doi: 10.14309/ajg.0000000000002365.
Loveikyte R, Bourgonje AR, van Goor H, Dijkstra G, van der Meulen-de Jong AE. The effect of iron therapy on oxidative stress and intestinal microbiota in inflammatory bowel diseases: A review on the conundrum. Redox Biol 2023;68:102950. doi: 10.1016/j.redox.2023.102950.
Bourgonje AR, Connelly MA, van Goor H, van Dijk PR, Dullaart RPF. Plasma Citrate Levels Are Associated with an Increased Risk of Cardiovascular Mortality in Patients with Type 2 Diabetes (Zodiac-64). J Clin Med 2023;12(20):6670. doi: 10.3390/jcm12206670.
Ghoti H, Zreid H, Ghoti I, Bourgonje AR, Diepstra A, van Goor H, Jeadi H, van Eijk LE, Weiss G. Clinical outcome and humoral immune responses of β-thalassemia major patients with severe iron overload to SARS-CoV-2 infection and vaccination: a prospective cohort study. EClinicalMedicine 2023;62:102096. doi: 10.1016/j.eclinm.2023.102096.
Geertsema S, Bourgonje AR, Fagundes RR, Gacesa R, Weersma RK, van Goor H, Mann GE, Dijkstra G, Faber KN. The NRF2/Keap1 pathway as therapeutic target in inflammatory bowel disease. Trends Mol Med 2023;S1471-4914(23)00158-2. doi: 10.1016/j.molmed.2023.07.008.
Otten AT, Dijkstra G, Visschedijk MC, Bourgonje AR. The Future of Therapeutic Drug Monitoring in Inflammatory Bowel Disease: An Emphasis on the Essential Ingredients. Inflamm Bowel Dis 2024;30(2):318-319. doi: 10.1093/ibd/izad144.
de Koning MSLY, Al-Ali L, Bourgonje AR, Westenbrink BD, Assa S, van Veldhuisen DJ, Lipsic E, van Goor H, van der Harst P. Associations of systemic oxidative stress with functional outcomes after ST-segment myocardial infarction. Int J Cardiol 2023;131214. doi: 10.1016/j.ijcard.2023.131214.
Bourgonje AR, Connelly MA, van Goor H, van Dijk PR, Dullaart RPF. Both LDL and HDL particle concentrations associate positively with an increased risk of developing microvascular complications in patients with type 2 diabetes: lost protection by HDL (Zodiac-63). Cardiovasc Diabetol 2023;22(1):169. doi: 10.1186/s12933-023-01909-1.
Otten AT, van der Meulen HH, Steenhuis M, Loeff FC, Touw DJ, Kosterink JGW, Frijlink HW, Dijkstra G, Visschedijk MC, Bourgonje AR. Clinical Validation of a Capillary Blood Home-Based Self-Sampling Technique for Monitoring of Infliximab, Vedolizumab, and C-Reactive Protein Concentrations in Patients With Inflammatory Bowel Disease. Inflamm Bowel Dis 2024;30(3):325-335. doi: 10.1093/ibd/izad103.
Hollander EM, van Tuinen EL, Scholvinck EH, Bergman KA, Bourgonje AR, Gracchi V, Kneyber MCJ, Touw DJ, Mian P. Evaluation of Dosing Guidelines for Gentamicin in Neonates and Children. Antibiotics (Basel) 2023;12(5):810. doi: 10.3390/antibiotics12050810.
Dunning BJ, Bourgonje AR, Bulthuis MLC, Alexander J, Aaseth JO, Larsson A, van Goor H, Alehagen U. Selenium and coenzyme Q10 improve the systemic redox status while reducing cardiovascular mortality in elderly population-based individuals. Free Radic Biol Med 2023;204:207-214. doi: 10.1016/j.freeradbiomed.2023.04.024.
Xu S, Li X, Zhang S, Qi C, Zhang Zm Ma R, Xiang L, Chen L, Zhu Y, Tang C, Bourgonje AR, Li M, He Y, Zeng S, Hu S, Feng R, Chen M. Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: A multi-omics Mendelian randomization study. BMC Med 2023;21(1):179. doi: 10.1186/s12916-023-02878-8.
Bourgonje AR*, Andreu-Sánchez S*, Vogl T, Hu S, Vich Vila A, Gacesa R, Leviatan S, Kurilshikov A, Klompus S, Kalka IN, van Dullemen HM, Weinberger A, Visschedijk MC, Festen EAM, Faber KN, Wijmenga C, Dijkstra G, Segal E, Fu J, Zhernakova A, Weersma RK. Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures. Immunity 2023;56(6):1393-1409.e6. doi: 10.1016/j.immuni.2023.04.017.
Andreu-Sánchez S*, Bourgonje AR*, Vogl T, Kurilshikov A, Leviatan S, Ruiz Moreno AJ, Hu S, Sinha T, Vich Vila A, Klompus S, Kalka IN, de Leeuw K, Arends S, Jonkers IH, Withoff S, Brouwer E, Weinberger A, Wijmenga C, Segal E, Weersma RK, Fu J, Zhernakova A. Phage-display immunoprecipitation sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoires. Immunity 2023;56(6):1376-1392.e8. doi: 10.1016/j.immuni.2023.04.003.
Geertsema S, van Goor H, Dijkstra G, Faber KN, Bourgonje AR. Letter: disentangling the role of redox-active compounds in the development of inflammatory bowel diseases – moving towards causal associations. Aliment Pharmacol Ther 2023;57(9):1046-1047. doi: 10.1111/apt.17455.
de Koning MSLY, Emmens JE, Romero-Hernández E, Bourgonje AR, Assa S, Figarska SM, Cleland JGF, Samani NJ, Ng LL, Metra M, Filippatos GS, Lang CC, van Veldhuisen DJ, Anker SD, Dickstein K, Voors AA, Lipsic E, van Goor H, van der Harst P. Systemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failure. Clin Res Cardiol 2023;112(8):1056-1066. doi: 10.1007/s00392-023-02171-x.
van der Holst AM, Otten AT, van Renterghem ARPKM, Bourgonje AR, van Loo ES, van Praag EM, Dijkstra G, Buskens CJ, Stassen LPS. Temporary diverting stoma in therapy-refractory luminal colonic Crohn’s disease: an alternative to immediate colorectal resection? Colorectal Dis 2023;25(6):1176-1186. doi: 10.1111/codi.16552.
Bourgonje MF, Abdulle AE, Kieneker LM, Bulthuis MLC, la Bastide-van Gemert S, Mulder DJ, de Borst MH, Gansevoort RT, Bakker SJL, Gordijn SJ, van Goor H, Bourgonje AR. A Sex-Specific Comparative Analysis of Oxidative Stress Biomarkers Predicting the Risk of Cardiovascular Events and All-Cause Mortality in the General Population: A Prospective Cohort Study. Antioxidants 2023;12(3):690. doi: 10.3390/antiox12030690.
Otten AT, Peters V, Barth I, Stevens CL, Bourgonje AR, Frijlink HW, Harmsen HJM, Rehman A, Campmans-Kuijpers MJE, Dijkstra G. Effects of ileo-colonic delivered vitamin B2, B3, and C or the Groningen Anti-Inflammatory Diet on disease course and microbiome of patients with Crohn’s disease (VITA-GrAID study): a protocol for a randomized and partially blinded trial. BMJ Open 2023;13(3):e069654. doi: 10.1136/bmjopen-2022-069654.
Bourgonje AR, van Goor H, Faber KN, Dijkstra G. Clinical Value of Multiomics-Based Biomarker Signatures in Inflammatory Bowel Diseases: Challenges and Opportunities. Clin Transl Gastroenterol 2023;14(7):e00579. doi: 10.14309/ctg.0000000000000579.
Bourgonje AR, Abdulle AE, Bourgonje MF, Kieneker LM, la Bastide-van Gemert S, Gordijn SJ, Hidden C, Nilsen T, Gansevoort RT, Mulder DJ, Dullaart RPF, de Borst MH, Bakker SJL, van Goor H. Plasma Neutrophil Gelatinase-Associated Lipocalin Associates with New-Onset Chronic Kidney Disease in the General Population. Biomolecules 2023;13(2):338. doi: 10.3390/biom13020338.
Borkent J, Ioannou M, Folkertsma T, Haarman BCM, van Goor H, Sommer IEC, Bourgonje AR. Systemic oxidative stress in recently diagnosed patients with schizophrenia spectrum disorders. Psychiatry Res 2023;321:115075. doi: 10.1016/j.psychres.2023.115075.
Geertsema S, Otten AT, Bouwknegt DG, Visschedijk MC, Bourgonje AR. Assessment of Fecal Glycosylated Mucins as Novel Biomarkers in Inflammatory Bowel Diseases. Inflamm Bowel Dis 2023;29(3):e10-e11. doi: 10.1093/ibd/izac265.
Bourgonje AR, van der Vaart A, Gruppen EG, van Goor H, Bakker SJL, Connelly MA, van Dijk PR, Dullaart RPF. Plasma levels of GlycA, a pro-inflammatory glycoprotein biomarker, associate with an increased risk of microvascular complications in patients with type 2 diabetes (Zodiac-62). Endocrine 2023;80(2):312-316. doi: 10.1007/s12020-023-03319-5.
Loveikyte R*, Bourgonje AR*, van der Reijden JJ, Bulthuis MLC, Hawinkels LJAC, van Goor H, van der Meulen-de Jong AE, Dijkstra G. Hepcidin and Iron Status in Patients With Inflammatory Bowel Disease Undergoing Induction Therapy With Vedolizumab or Infliximab. Inflamm Bowel Dis 2023;29(8):1272-1284. doi: 10.1093/ibd/izad010.
Feenstra L, Kutikhin AG, Shishkova DK, Buikema H, Zeper LW, Bourgonje AR, Krenning G, Hillebrands JL. Calciprotein Particles Induce Endothelial Dysfunction by Impairing Endothelial Nitric Oxide Metabolism. Arterioscler Thromb Vasc Biol 2023;43(3):443-455. doi: 10.1161/ATVBAHA.122.318420.
Bourgonje AR, Otten AT. The Risk of Developing Long COVID in Patients with Inflammatory Bowel Diseases: Do Immunosuppressive Drugs Matter? Clin Gastroenterol Hepatol 2023;21(7):1971-1972. doi: 10.1016/j.cgh.2022.12.030.
Bourgonje AR, Grochot-Przeczek A, Kloska D, Feelisch M, Cuadrado A, van Goor H. Personalized redox medicine in inflammatory bowel disease: emerging role of HIF1α and NRF2 as therapeutic targets. Redox Biol 2023;60:102603. doi: 10.1016/j.redox.2023.102603.
2022
Bourgonje AR, van den Berg EH, Kieneker LM, Nilsen T, Hidden C, Sundrehagen E, Gansevoort RT, Bakker SJL, Blokzijl H, Dullaart RPF, van Goor H, Abdulle AE. Plasma Calprotectin levels Associate with Suspected Metabolic-Associated Fatty Liver Disease and All-Cause Mortality in the General Population. Int J Mol Sci 2022;23(24):15708. doi: 10.3390/ijms232415708.
Otten AT*, Bourgonje AR*, Visschedijk MC. Working towards a comprehensive appraisal of vaccine-induced immunity against SARS-CoV-2 in IBD. Lancet Gastroenterol Hepatol 2023;8(2):99-100. doi: 10.1016/S2468-1253(22)00404-6.
Bourgonje AR. Microbial Riboflavin Biosynthesis Associates With Response to Dietary Fiber Consumption: Time to Personalize Adjunct Therapy in Patients With Inflammatory Bowel Disease? Gastroenterology 2023;165(2):515-516. doi: 10.1053/j.gastro.2022.10.016.
Spraakman NA, Coester AM, Bourgonje AR, Nieuwenhuijs VB, Sanders JSF, Leuvenink HGD, van Goor H, Nieuwenhuijs-Moeke GJ. Systemic and Renal Dynamics of Free Sulfhydryl Groups during Living Donor Kidney Transplantation. Int J Mol Sci 2022;23(17):9789. doi: 10.3390/ijms23179789.
Bourgonje AR, Wichers SJ, Hu S, van Dullemen HM, Visschedijk MC, Faber KN, Festen EAM, Dijkstra G, Samsom JN, Weersma RK, Spekhorst LM. Proteomic analyses do not reveal subclinical inflammation in fatigued patients with clinically quiescent inflammatory bowel disease. Sci Rep 2022;12(1):14581. doi: 10.1038/s41598-022-17504-5.
Bourgonje AR, Otten AT, Sadaghian Sadabad M, von Martels JZH, Bulthuis MLC, Faber KN, van Goor H, Dijkstra G, Harmsen HJM. The effect of riboflavin supplementation on the systemic redox status in healthy volunteers: A post-hoc analysis of the RIBOGUT trial. Free Radic Biol Med 2022;190:169-178. doi: 10.1016/j.freeradbiomed.2022.08.008.
Bourgonje AR. Evaluating Discriminative Accuracy of Biomarkers in Relation to Binary Study Outcomes: First Validate, Then Celebrate? J Crohns Colitis 2023;17(1):146. doi: 10.1093/ecco-jcc/jjac117.
van Eijk LE, Offringa AK, Bernal ME, Bourgonje AR, van Goor H, Hillebrands JL. The Disease-Modifying Role of Taurine and Its Therapeutic Potential in Coronavirus Disease 2019 (COVID-19). Adv Exp Biol Med 2022;1370:3-21. doi: 10.1007/978-3-030-93337-1_1.
Alexdottir M*, Bourgonje AR*, Karsdal MA, Bay-Jensen AC, Pehrsson M, Loveikyte R, van Dullemen HM, Visschedijk MC, Festen EAM, Weersma RK, Faber KN, Dijkstra G, Mortensen JH. Serological Biomarkers of Extracellular Matrix Turnover and Neutrophil Activity Are Associated with Long-Term Use of Vedolizumab in Patients with Crohn’s Disease. Int J Mol Sci 2022;23(15):8137. doi: 10.3390/ijms23158137.
Gabriëls RY*, Bourgonje AR*,von Martels JZH, Trentadue G, Blokzijl T, van Dullemen HM, Festen EAM, Visschedijk MC, Weersma RK, Galinsky K, Juarez J, Kats-Ugurlu G, Faber KN, Dijkstra G. Mucosal Eosinophil Abundance in Non-Inflamed Colonic Tissue Is Associated with Response to Vedolizumab Induction Therapy in Inflammatory Bowel Disease. J Clin Med 2022;11(14):4141. doi: 10.3390/jcm11144141.
Alexdottir M*, Bourgonje AR*, Karsdal MA, Bay-Jensen AC, Loveikyte R, van Dullemen HM, Visschedijk MC, Festen EAM, Weersma RK, Faber KN, Dijkstra G, Mortensen JH. Serological Biomarkers of Intestinal Collagen Turnover Identify Early Response to Infliximab Therapy in Patients With Crohn’s Disease. Front Med (Lausanne) 2022;9:933872. doi: 10.3389/fmed.2022.933872.
Otten AT*, Bourgonje AR*, Horinga PP, van der Meulen HH, van Leer-Buter C, Dijkstra G, Visschedijk MC. Use of Tumor Necrosis Factor-α Antagonists Is Associated With Attenuated IgG Antibody Response Against SARS-CoV-2 in Vaccinated Patients With Inflammatory Bowel Disease. Front Immunol 2022;13:920333. doi: 10.3389/fimmu.2022.920333.
Visser K, van der Horn, Bourgonje AR, Jacobs B, Vos PE, Bulthuis MLC, van Goor H, van der Naalt J. Acute serum free thiols: a potentially modifiable biomarker of oxidative stress following traumatic brain injury. J Neurol 2022;269(11):5883-5892. doi: 10.1007/s00415-022-11240-6.
Bourgonje AR*, Bolte LA*, Vranckx LLC, Spekhorst LM, Gacesa R, Hu S, van Dullemen HM, Visschedijk MC, Festen EAM, Samsom JN, dijkstra G, Weersma RK, Campmans-Kuijpers MJE. Long-Term Dietary Patterns Are Reflected in the Plasma Inflammatory Proteome of Patients with Inflammatory Bowel Disease. Nutrients 2022;14(12):2522. doi: 10.3390/nu14122522.
Bourgonje AR, Bourgonje MF, Post A, la Bastide-van Gemert S, Kieneker LM, Bulthuis MLC, Gordijn SJ, Gansevoort RT, Bakker SJL, Mulder DJ, Pasch A, van Goor H, Abdulle AE. Systemic oxidative stress associates with new-onset hypertension in the general population. Free Radic Biol Med 2022;187:123-131. doi: 10.1016/j.freeradbiomed.2022.05.020.
Bergsma A, Li HT, van Eliveld J, Bulthuis MLC, Hoek A, van Goor H, Bourgonje AR, Cantineau AEP. Local and Systemic Oxidative Stress Biomarkers for Male Infertility: the ORION Study. Antioxidants 2022;11(6):1045. doi: 10.3390/antiox11061045.
Fagundes RR*, Bourgonje AR*, Hu S, Barbieri R, Jansen BH, Weersma RK, Taylor CT, Faber KN, Dijkstra G. HIF1α-Dependent Induction of TFRC by a Combination of Intestinal Inflammation and Systemic Iron Deficiency in Inflammatory Bowel Disease. Front Physiol 2022;13:889091. doi: 10.3389/fphys.2022.889091.
Bourgonje AR*, Alexdottir M*, Otten AT, Loveikyte R, Bay-Jensen AC, van Dullemen HM, Visschedijk MC, Festen EAM, Weersma RK, Karsdal MA, Faber KN, Mortensen JH, Dijkstra G. Serological biomarkers of type I, III and IV collagen turnover are associated with the presence and future progression of stricturing and penetrating Crohn’s disease. Aliment Pharmacol Ther 2022;56(4):675-693. doi: 10.1111/apt.17063.
Bourgonje AR, Vogl T, Segal E, Weersma RK. Antibody signatures in inflammatory bowel disease: current developments and future applications. Trends Mol Med 2022;28(8):693-705. doi: 10.1016/j.molmed.2022.05.004.
Bourgonje AR, Roo-Brand G, Lisotto P, Sadaghian Sadabad M, Reitsema RD, de Goffau MC, Faber KN, Dijkstra G, Harmsen HJM. Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera. Front Immunol 2022;13:842911. doi: 10.3389/fimmu.2022.842911.
van der Slikke EC, Boekhoud L, Bourgonje AR, Olgers TJ, ter Maaten JC, Henning RH, van Goor H, Bouma HR. Plasma Free Thiol Levels during Early Sepsis Predict Future Renal Function Decline. Antioxidants 2022;11(5):800. doi: 10.3390/antiox1105800.
Leimkühler M, Bourgonje AR, van Goor H, Campmans-Kuijpers MJE, de Bock GH, van Leeuwen BL. ASO Visual Abstract: Oxidative Stress Predicts Post-surgery Complications in Gastrointestinal Cancer Patients. Ann Surg Oncol 2022;29(7):4550-1. doi: 10.1245/s10434-022-11685-z.
Savelkoul EHJ, Maas MHJ, Bourgonje AR, Crouwel F, Biemans VBC, den Broeder N, Russel MGVM, Römkens TEH, de Boer NKH, Dijkstra G, Hoentjen F. Favourable Tolerability and Drug Survival of Tioguanine Versus Methotrexate After Failure of Conventional Thiopurines in Crohn’s Disease. J Crohns Colitis 2022;16(9):1372-1379. doi: 10.1093/ecco-jcc/jjac044.
Leimkühler M, Bourgonje AR, van Goor H, Campmans-Kuijpers MJE, de Bock GH, van Leeuwen BL. ASO Author Reflections: Oxidative Stress as a Predictor of Short-Term Outcome After Oncological Surgery for Gastrointestinal Cancer. Ann Surg Oncol 2022;29(7):4548-9. doi: 10.1245/s10434-022-11453-z.
Leimkühler M, Bourgonje AR, van Goor H, Campmans-Kuijpers MJE, de Bock GH, van Leeuwen BL. Oxidative Stress Predicts Post-Surgery Complications in Gastrointestinal Cancer Patients. Ann Surg Oncol 2022;29(7):4540-4547. doi: 10.1245/s10434-022-11412-8.
Al Hasan A, Reimann F, Veeger NJGM, Bergstra SA, Zhang D, Bourgonje AR, Hendriks L, Riofrio LZ, Wink F, Schilder A, Huizinga TWJ, Bos R. Optical imaging compared to clinical examination in 484 rheumatoid arthritis patients: the Leeuwarden Handscan Registry. Rheumatol Int 2022;42(11):2019-2026. doi: 10.1007/s00296-021-05060-6.
2021
van Eijk LE, Tami A, Hillebrands JL, den Dunnen WFA, de Borst MH, van der Voort PHJ, Bulthuis MLC, Veloo ACM, Wold KI, Vincenti González MF, van der Gun BTF, van Goor H, Bourgonje AR. Mild Coronavirus Disease 2019 (COVID-19) is Marked by Systemic Oxidative Stress: A Pilot Study. Antioxidants 2021;10(12):2022. doi: 10.3390/antiox10122022.
Bourgonje AR, Abdulle AE, Bourgonje MF, Binnenmars SH, Gordijn SJ, Bulthuis MLC, la Bastide-van Gemert S, Kieneker LM, Gansevoort RT, Bakker SJL, Mulder DJ, Pasch A, de Borst MH, van Goor H. Serum free sulfhydryl status associates with new-onset chronic kidney disease in the general population. Redox Biol 2021;48:102211. doi: 10.1016/j.redox.2021.102211.
Fagundes RR, Bourgonje AR, Saeed A, Vich Vila A, Plomp N, Blokzijl T, Sadaghian Sadabad M, von Martels JZH, van Leeuwen SS, Weersma RK, Dijkstra G, Harmsen HJM, Faber KN. Inulin-grown Faecalibacterium prausnitzii cross-feeds fructose to the human intestinal epithelium. Gut Microbes 2021;13(1):1993582. doi: 10.1080/19490976.2021.1993582.
Schoots MH, Bourgonje MF, Bourgonje AR, Prins JR, van Hoorn EGM, Abdulle AE, Muller Kobold AC, van der Heide M, Hillebrands JL, van Goor H, Gordijn SJ. Oxidative stress biomarkers in fetal growth restriction with and without preeclampsia. Placenta 2021;115:87-96. doi: 10.1016/j.placenta.2021.09.013.
Wang Z, Bourgonje AR, Abdulle AE, Groen H, Cantineau AEP, van Oers AM, van Dammen L, van Elten T, Wekker V, Mol BWJ, Roseboom TJ, van Goor H, Hoek A. The Effect of Lifestyle Intervention on Systemic Oxidative Stress in Women with Obesity and Infertility: A Post-Hoc Analysis of a Randomized Controlled Trial. J Clin Med 2021;10(18):4243. doi: 10.3390/jcm10184243.
Bourgonje AR*, Hu S*, Spekhorst LM*, Zhernakova DV, Vich Vila A, Li Y, Voskuil MD, van Berkel LA, Bley Folly B, Charrout M, Mahfouz A, Reinders MJT, van Heck JIP, Joosten LAB, Visschedijk MC, van Dullemen HM, Faber KN, Samsom JN, Festen EAM, Dijkstra G, Weersma RK. The Effect of Phenotype and Genotype on the Plasma Proteome in Patients with Inflammatory Bowel Disease. J Crohns Colitis 2022;16(3):414-429. doi: 10.1093/ecco-jcc/jjab157.
Otten AT*, Bourgonje AR*, Peters V, Alizadeh BZ, Dijkstra G, Harmsen HJM. Vitamin C Supplementation in Healthy Individuals Leads to Shifts of Bacterial Populations in the Gut-A Pilot Study. Antioxidants 2021;10(8):1278. doi: 10.3390/antiox10081278.
Nielsen MB, Jespersen B, Birn H, Krogstrup NV, Bourgonje AR, Leuvenink HGD, van Goor H, Nørregaard R. Elevated plasma free thiols are associated with early and one-year graft function in renal transplant recipients. PLoS One 2021;16(8):e0255930. doi: 10.1371/journal.pone.0255930.
Offringa AK, Bourgonje AR, Schrier MS, Deth RC, van Goor H. Clinical implications of vitamin B12 as redox-active cofactor. Trends Mol Med 2021;27(10):931-934. doi: 10.1016/j.molmed.2021.07.002.
Bourgonje AR, van Linschoten RCA, West RL, van Dijk MA, van Leer-Buter CC, Kats-Ugurlu G, Pierik MJ, Festen EAM, Weersma RK, Dijkstra G. Treatment of severe acute ulcerative colitis in SARS-CoV-2 infected patients: report of three cases and discussion of treatment options. Therap Adv Gastroenterol 2021;14:17562848211012595. doi: 10.1177/17562848211012595.
Bourgonje AR, Offringa AK, van Eijk LE, Abdulle AE, Hillebrands JL, van der Voort PHJ, van Goor H, van Hezik EJ. N-Acetylcysteine and Hydrogen Sulfide in Coronavirus Disease 2019. Antioxid Redox Signal 2021;35(14):1207-1225. doi: 10.1089/ars.2020.8247.
van Eijk LE, Binkhorst M, Bourgonje AR, Offringa AK, Mulder DJ, Bos EM, Kolundzic N, Abdulle AE, van der Voort PHJ, Olde Rikkert MGM, van der Hoeven JG, den Dunnen WFA, Hillebrands JL, van Goor H. COVID-19: immunopathology, pathophysiological mechanisms, and treatment options. J Pathol 2021;254(4):307-331. doi: 10.1002/path.5642.
Bourgonje MF, Bourgonje AR, Abdulle AE, Kieneker LM, la Bastide-van Gemert S, Gansevoort RT, Bakker SJL, Mulder DJ, Pasch A, Saleh J, Gordijn SJ, van Goor H. Systemic Oxidative Stress, Aging and the Risk of Cardiovascular Events in the General Female Population. Front Cardiovasc Med 2021;8:630543. doi: 10.3389/fcvm.2021.630543.
2020
Boekhoud L, Koeze J, van der Slikke EC, Bourgonje AR, Moser J, Zijlstra JG, Muller Kobold AC, Bulthuis MLC, van Meurs M, van Goor H, Bouma HR. Acute Kidney Injury is Associated with Lowered Plasma-Free Thiol Levels. Antioxidants 2020;9(11):1135. doi: 10.3390/antiox9111135.
Bourgonje AR, Feelisch M, Faber KN, Pasch A, Dijkstra G, van Goor H. Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease. Trends Mol Med 2020;26(11):1034-1046. doi: 10.1016/j.molmed.2020.06.006.
Damba T*, Bourgonje AR*, Abdulle AE, Pasch A, Sydor S, Gansevoort RT, Bakker SJL, Blokzijl H, Dullaart RPF, van Goor H, Moshage H. Oxidative stress is associated with suspected non-alcoholic fatty liver disease and all-cause mortality in the general population. Liver Int 2020;40(9):2148-2159. doi: 10.1111/liv.14562.
Bourgonje AR*, Abdulle AE*, Timens W, Hillebrands JL, Navis GJ, Gordijn SJ, Bolling MC, Dijkstra G, Voors AA, Osterhaus ADME, van der Voort PHJ, Mulder DJ, van Goor H. Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19). J Pathol 2020;251(3):228-248. doi: 10.1002/path.5471.
Abdulle AE*, Bourgonje AR*, Bakker SJL, Bulthuis MLC, Dijkstra G, Faber KN, Gans ROB, Gansevoort RT, Kieneker LM, Koning AM, Mulder DJ, Pasch A, van Goor H. Serum free thiols predict cardiovascular events and all-cause mortality in the general population: a prospective cohort study. BMC Med 2020;18(1):130. doi: 10.1186/s12916-020-01587-w.
Leimkühler M, Bourgonje AR, van Goor H, van Leeuwen BL, de Bock GH. Systemic oxidative stress and antioxidant capacity in cancer patients. J Transl Sci 2020;6:372. doi: 10.15761/JTS.1000372.
Vich Vila A, Collij V, Sanna S, Imhann F, Sinha T, Bourgonje AR, Mujagic Z, Jonkers DMAE, Masclee AAM, Fu J, Kurilshikov A, Wijmenga C, Zhernakova A, Weersma RK. Impact of commonly used drugs on the composition and metabolic function of the gut microbiota. Nat Commun 2020;11:362. doi: 10.1038/s41467-019-14177-z.
Bourgonje AR*, Abdulle AE*, Al-Rawas AM, Al-Maqbali M, Al-Saleh M, Enriquez MB, Al-Siyabi S, Al-Hashmi K, Al-Lawati I, Bulthuis MLC, Mulder DJ, Gordijn SJ, van Goor H, Saleh J. Systemic Oxidative Stress Is Increased in Postmenopausal Women and Independently Associates With Homocysteine Levels. Int J Mol Sci 2020;21(1):314. doi: 10.3390/ijms21010314.
von Martels JZH*, Bourgonje AR*, Klaassen MAY*, Alkhalifah HAA, Sadaghian Sadabad M, Vich Vila A, Gacesa R, Gabriëls RY, Steinert RE, Jansen BH, Bulthuis MLC, van Dullemen HM, Visschedijk MC, Festen EAM, Weersma RK, de Vos P, van Goor H, Faber KN, Harmsen HJM, Dijkstra G. Riboflavin Supplementation in Patients with Crohn’s Disease [the RISE-UP study]. J Crohns Colitis 2020;14(5):595-607. doi: 10.1093/ecco-jcc/jjz208.
2019
Bourgonje AR*, von Martels JZH*, Gabriëls RY, Blokzijl T, Buist-Homan M, Heegsma J, Jansen BH, van Dullemen HM, Festen EAM, ter Steege RWF, Visschedijk MC, Weersma RK, de Vos P, Faber KN, Dijkstra G. A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel Disease. Front Med (Lausanne) 2019;6:251. doi: 10.3389/fmed.2019.00251.
Bourgonje AR, Gabriëls RY, de Borst MH, Bulthuis MLC, Faber KN, van Goor H, Dijkstra G. Serum Free Thiols Are Superior to Fecal Calprotectin in Reflecting Endoscopic Disease Activity in Inflammatory Bowel Disease. Antioxidants 2019;8(9):351. doi: 10.3390/antiox8090351.
Bourgonje AR, von Martels JZH, Bulthuis MLC, van Londen M, Faber KN, Dijkstra G, van Goor H. Crohn’s Disease in Clinical Remission Is Marked by Systemic Oxidative Stress. Front Physiol 2019;10:499. doi: 10.3389/fphys.2019.00499.
von Martels JZH*, Bourgonje AR*, Harmsen HJM, Faber KN, Dijkstra G. Assessing intestinal permeability in Crohn’s disease using orally administered 52Cr-EDTA. PLoS One 2019;14(2):e0211973. doi: 10.1371/journal.pone.0211973.
2018
Bourgonje AR, von Martels JZH, de Vos P, Faber KN, Dijkstra G. Increased fecal calprotectin levels in Crohn’s disease correlate with elevated serum Th1- and Th17-associated cytokines. PLoS One 2018;13(2):e0193202. doi: 10.1371/journal.pone.0193202.
2017
von Martels JZH, Sadaghian Sadabad M, Bourgonje AR, Blokzijl T, Dijkstra G, Faber KN, Harmsen HJM. The role of gut microbiota in health and disease: In vitro modeling of host-microbe interactions at the aerobe-anaerobe interphase of the human gut. Anaerobe 2017;44:3-12. doi: 10.1016/j.anaerobe.2017.01.001.